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What drugs potentially interact with cyclosporin?
Cyclosporin
interactions are mediated through cytochrome P450 inhibition
or induction mechanism. Drugs that inhibit CP450, and therefore
increase cyclosporin levels, are:
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macrolide antibiotics; |
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imidazoles
(ketoconazole, fluconazole); |
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diltiazem; |
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verapamil; |
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cimetidine;
and |
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danazol.
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Drugs
that decrease cyclosporin levels by induction of CP450 are
anti-epileptic agents, rifampicin and St John's Wort. Drugs,
which are nephrotoxic, may add to cyclosporins' nephrotoxicity.
Agents which promote retention of potassium may lead to hyperkalaemia
when co-prescribed with cyclosporin.
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